منابع مشابه
First principles prediction of protein folding rates.
Experimental studies have demonstrated that many small, single-domain proteins fold via simple two-state kinetics. We present a first principles approach for predicting these experimentally determined folding rates. Our approach is based on a nucleation-condensation folding mechanism, where the rate-limiting step is a random, diffusive search for the native tertiary topology. To estimate the ra...
متن کاملPrinciples of protein folding, misfolding and aggregation.
This review summarises our current understanding of the underlying and universal mechanism by which newly synthesised proteins achieve their biologically functional states. Protein molecules, however, all have a finite tendency either to misfold, or to fail to maintain their correctly folded states, under some circumstances. This article describes some of the consequences of such behaviour, par...
متن کاملLoop-closure principles in protein folding.
Simple theoretical concepts and models have been helpful to understand the folding rates and routes of single-domain proteins. As reviewed in this article, a physical principle that appears to underly these models is loop closure.
متن کاملProtein folding and misfolding: mechanism and principles.
Two fundamentally different views of how proteins fold are now being debated. Do proteins fold through multiple unpredictable routes directed only by the energetically downhill nature of the folding landscape or do they fold through specific intermediates in a defined pathway that systematically puts predetermined pieces of the target native protein into place? It has now become possible to det...
متن کامل[16] Cooperativity Principles in Protein Folding
Knowledge of the physical driving forces in proteins is essential for understanding their structures and functions. As polymers, proteins have remarkable thermodynamic and kinetic properties. A well-known observation is that the folding and unfolding of many small single-domain proteins, of which chymotrypsin inhibitor 2 is a prime example, appear to involve only two main states—N (native) and ...
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ژورنال
عنوان ژورنال: BMC Proceedings
سال: 2012
ISSN: 1753-6561
DOI: 10.1186/1753-6561-6-s6-o26